What Suprane is used for and how to use it
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Suprane - Consumer Medicine Information

Manufacture: Baxter
Country: Angola
Condition: Anesthesia
Class: General anesthetics
Form: Liquid solution, Inhaler
Ingredients: desflurane

SUPRANE

(desflurane, USP)100% v/v

Liquid for Inhalation

About this Medication

What the medication is used for

SUPRANE is an inhaled general anesthetic used during surgery.

What it does

SUPRANE maintains unconsciousness, muscle relaxation, and loss of sensation over the entire body while surgery is being performed.

When it should not be used

  • If you have been told that you are allergic to desflurane or other inhaled general anesthetics, or components of the container.
  • If you have a history of liver inflammation (hepatitis) due to the use of an inhaled general anesthetic, or have experienced unexplained liver problems (for example jaundice with fever) after a previous use of an inhaled general anesthetic.
  • If you or any member of your family has experienced a condition called malignant hyperthermia (a genetic disorder that causes rapid raise in body temperature) during an operation.

What the medicinal ingredient is

Desflurane, USP.

What the important nonmedicinal ingredients are

The finished product is composed solely of the active ingredient, desflurane, USP.

What dosage forms it comes in

SUPRANE is available as a volatile liquid that is 100% v/v in concentration.

Warnings and Precautions

Serious Warnings and Precautions

  • SUPRANE should only be administered by qualified individuals trained in general anesthesia in an adequately equipped facility;
  • SUPRANE may trigger a rise in blood potassium or body temperature. You may experience stiff muscles, changes in blood pressure, rapid breathing, a bluish colour to lips or fingers, rapid or irregular heart rate. Trained health care professionals will take care of you if this happens.

You should talk to your anaesthesia professional prior to surgery if you are aware of any of the following conditions:

  • If you have been told that you are allergic to desflurane or other inhaled general anesthetics, or components of the container.
  • You are pregnant or could be pregnant.
  • You are breast-feeding.
  • You are taking or have recently taken any other medicines, even those not prescribed.
  • You have previously had general anesthesia, particularly if repeated over a short period of time.
  • You are suffering from any illness, other than those connected with your operation, such as diabetes, severe headaches, cancer, problems with your nerves or muscles (especially muscular dystrophy), nausea or vomiting.
  • You or a member of your family suffers from malignant hyperthermia (a genetic disorder that causes rapid raise in body temperature).
  • You suffer from a heart, liver, or kidney problem.
  • If your child who needs anesthetics has asthma or has recently had an upper respiratory (airway) infection.

Recovery of consciousness following SUPRANE administration generally occurs within minutes. As with other anesthetics, small changes in moods may persist for several days following administration.

Performance of activities requiring mental alertness, such as operating a motor vehicle or hazardous machinery, may be impaired for some time after general anesthesia. Do not drive a motor vehicle or operate hazardous machinery for at least 24 hours after having a general anesthetic.

Interactions with this Medication

Serious Drug Interactions

  • Tell your healthcare professional if you have muscular diseases (especially muscular dystrophy), and:
    • You are taking potassium, and/or
    • You have heart problems, especially irregular heart beats

Tell your doctor, nurse or pharmacist about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

Drugs that may interact with SUPRANE include:

Other anesthetics, tranquillizers (e.g. benzodiazepines) and narcotics (e.g. opioids), nitrous oxide gas, muscle relaxants (e.g. pancuronium), beta blockers (e.g. to treat high blood pressure), Monoamine Oxidase Inhibitors (MAO) inhibitors (e.g. to treat depression) and indirect-acting sympathomimetics (e.g. amphetamines, stimulants and appetite suppressants).

Proper Use of this Medication

Usual dose

Your anesthetist will decide what dose of SUPRANE you will receive. The dose will vary depending on your age, weight, and the type of operation that you are having.

You will receive another anesthetic to make you go to sleep before receiving SUPRANE by inhalation.

Overdose

This will be handled by the anesthetist.

In case of drug overdose (especially if you have accidentally come in contact with SUPRANE on your skin, in your eyes, by swallowing it or by breathing it in), contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

Side Effects and what to do about them

Side effects include headache, cough, nausea, vomiting, and excessive production of saliva.

Serious side effects, how often they happen and what to do about them

After exposure to SUPRANE, you should contact your physician or anesthesia professional if you have any of the following reactions:

  • Agitation
  • Difficulty breathing/choking/shortness of breath, wheezing
  • Decreased oxygen in your blood: shortness of breath, bluish colour to lips or fingers.
  • Elevated Rise in Blood Glucose, if measured
  • Heart Attack
  • High or low Blood Pressure
  • Bleeding
  • Slow, rapid or irregular Heartbeat
  • Dizziness
  • Jaundice: yellow colour to skin and eyes, dark urine
  • Mild to Severe Allergic reactions
  • Rash, hives, severe itching
  • Severe muscle pain or sore throat
  • Sudden fever with stiffness, pain and weakness in your muscles

This is not a complete list of side effects. For any unexpected effects while taking SUPRANE, contact your doctor or pharmacist.

How to Store it

SUPRANE should only be administered in an adequately equipped facility. SUPRANE must be kept out of reach and sight of children. It is stored at or below 30°C (86°F).

Reporting Suspected Side Effects

You can report any suspected adverse reactions associated with the use of health products to the Canada Vigilance Program by one of the following 3 ways:

  • Report online at www.healthcanada.gc.ca/medeffect
  • Call toll-free at 1-866-234-2345
  • Complete a Canada Vigilance Reporting Form and:
    • Fax toll-free to 1-866-678-6789, or
    • Mail to:
      Canada Vigilance Program
      Health Canada
      Postal Locator 0701E
      Ottawa, Ontario
      K1A 0K9

Postage paid labels, Canada Vigilance Reporting Form and the adverse reaction reporting guidelines are available on the MedEffect Canada Web site at www.healthcanada.gc.ca/medeffect.

NOTE: Should you require information related to the management of side effects, contact your health professional. The Canada Vigilance Program does not provide medical advice.

More Information

This document plus the full product monograph, prepared for health professionals can be obtained by contacting the sponsor, Baxter Corporation, at 1-888-719-9955.