What Depo Medrol Lidocaine is used for and how to use it
  • Россия
  • Украина

Depo Medrol Lidocaine - Consumer Medicine Information

Manufacture: Pfizer Inc.
Country: Canada
Condition: Inflammatory Conditions, Joint Pain (Osteoarthritis), Local Anesthesia
Class: Analgesics, Glucocorticoids
Form: Liquid solution
Ingredients: benzyl alcohol, myristyl-gamma-picolinium chloride, polyethylene glycol 3350, sodium chloride, methylprednisolone acetate, lidocaine hydrochloride of suspension

(sterile methylprednisolone acetate 40 mg/mL and
lidocaine hydrochloride 10 mg/mL)

About this Medication

What the Medication is Used For

DEPO-MEDROL with Lidocaine (methylprednisolone acetate and lidocaine hydrochloride) is used as an adjunctive treatment of acute or worsening (exacerbation) inflammation of joints and tendons. DEPO-MEDROL with Lidocaine is not a cure nor has any effect on the cause of the inflammation.

What it Does

DEPO-MEDROL with Lidocaine contains a corticosteroid hormone (glucocorticoid) and a local anaesthetic. It decreases the body’s immune response to certain diseases and it helps to reduce pain and inflammation.

When it Should not be Used

Do not take DEPO-MEDROL with Lidocaine if you have:

  • allergic reaction to methylprednisolone acetate or any other steroid medicine or lidocaine or any similar local anaesthetics or any of the other ingredients in DEPO-MEDROL with Lidocaine; or
  • any fungal infection or any untreated infections.
  • viral diseases including vaccinia (cowpox), varicella (chicken pox), and herpes simplex of the eye.
  • low platelet count.

DEPO-MEDROL with Lidocaine should not be given to premature infants because the formulation contains benzyl alcohol.

Patients taking DEPO-MEDROL with Lidocaine should not receive live vaccines.

What the medicinal ingredients are:

Methylprednisolone acetate and lidocaine hydrochloride.

What the Medicinal Ingredients Are

Benzyl alcohol, myristyl-gamma-picolinium chloride, polyethylene glycol 3350 and sodium chloride.

What Dosage Forms it Comes In

1, 2 and 5 mL vials containing 40 mg/mL methylprednisolone acetate and 10 mg/mL lidocaine hydrochloride of suspension.

Warning and Precautions

DEPO-MEDROL with Lidocaine is not to be injected into the vein (intravenous), or into the spinal cord (intrathecal).

Before taking DEPO-MEDROL with Lidocaine, talk to your doctor if you have:

  • an infection (such as herpes simplex, chicken pox, tuberculosis, threadworm);
  • bleeding problem, blood clotting problem;
  • brittle bone (osteoporosis);
  • high blood pressure;
  • seizures (fits);
  • thyroid problem (hypothyroidism);
  • muscle pain or weakness (such as myasthenia gravis);
  • skin cancer (Kaposi’s sarcoma);
  • heart problems such as heart failure;
  • certain eye diseases such as glaucoma, cataracts;
  • herpes infection;
  • kidney disease;
  • liver disease such as cirrhosis;
  • certain mental or mood conditions (such as depression);
  • stomach or gut problems (ulcer, ulcerative colitis);
  • low potassium or calcium;
  • Cushing’s disease (caused by an excess of cortisol hormone);
  • weak immune response;
  • high blood sugar.

Before you have any operation, tell your doctor, dentist or anesthetist that you are taking DEPO-MEDROL with Lidocaine.

Pregnancy and breast feeding

You must tell your doctor if you are pregnant, think you might be pregnant or are trying to become pregnant as this medicine could slow the baby’s growth.

You should also tell your doctor if you are breast feeding as small amounts of corticosteroid medicines may get into breast milk. It is not known whether Lidocaine can get into breast milk.


Corticosteroids can affect growth in children.
DEPO-MEDROL with Lidocaine contains benzyl alcohol and is not recommended to be used in infants since benzyl alcohol has been reported to cause “gasping syndrome” that may result in death.

Interactions with this Medication

Before taking DEPO-MEDROL with Lidocaine talk to your doctor about all your other medications, including those you bought without prescription, herbal or natural products. Especially if you are taking the following:

  • drugs to treat glaucoma and epilepsy such as acetazolamide
  • drugs to prevent or alleviate nausea and vomiting such as aprepitant or fosaprepitant
  • drugs to treat cancer such as aminoglutethimide or cyclophosphamide
  • drugs to “thin” the blood; anticoagulants such as acenocoumarol, phenindione and warfarin
  • drugs to treat myasthenia gravis (a muscle condition) such as distigmine and neostigmine
  • antibiotics and antifungals (such as ketoconazole, itraconazole amphotericin B, erythromycin, clarithromycin, troleandomycin, rifampicin and rifabutin)
  • aspirin and non-steroidal anti-inflammatory medicines (also called NSAIDs) such as ibuprofen
  • drugs to treat epilepsy such as barbiturates, carbamazepine, phenytoin and primidone
  • drugs for heartburn and acid indigestion such as cimetidine
  • cyclosporine
  • drugs for heart problems or high blood pressure such as calcium channel blockers, digoxin and diltiazem
  • water pills (diuretics)
  • hormone replacement therapy or hormonal oral
  • contraceptives
  • drugs to treat HIV infections such as indinavir or ritonavir
  • pancuronium or vercuronium – or other medicines called neuromuscular blocking agents which are used in some surgical procedures
  • tacrolimus – used following an organ transplant to prevent rejection of the organ
  • vaccines – tell your doctor or nurse if you have recently had, or are about to have any vaccination
  • drugs to treat diabetes
  • drugs to treat tuberculosis
  • drugs to treat high cholesterol (cholestyramine)
  • aromatase inhibitors (drugs to treat breast or ovarian cancer)
  • immunosuppressants (drugs that suppress or reduce the strength of the body's immune system

Do not drink grapefruit juice while taking DEPO-MEDROL with Lidocaine.

Driving and Using Machines

Side effects, such as dizziness, vertigo, visual disturbance and fatigue are possible after treatment with corticosteroids. If you experience these effects, you should not drive or operate machinery.

Proper Use of this Medication

DEPO-MEDROL with Lidocaine is to be given to you as an injection into the joint (intra-articular or intra -synovial, peri-articular and intrabursal injection) or the tendon (intratendinous or intra -ganglion injection) by your health care provider. The dose of DEPO-MEDROL with Lidocaine is depending on your condition and how severe it is.

When your condition has improved, your dose will be reduced gradually. DEPO-MEDROL with Lidocaine should not be stopped abruptly.


In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

Side effects and what to do about them

Like all medicines, DEPO-MEDROL with Lidocaine can have side effects although not everybody gets them.

DEPO-MEDROL with Lidocaine may hide symptoms of infections, may cause latent infections to become active, and may induce infections by normally inoffensive organisms due to lowered body resistance.

Potential side effects with DEPO-MEDROL with Lidocaine include:

Allergic Reactions:

  • anaphylaxis (a severe, life-threatening allergic reaction)
  • cardiac arrest
  • bronchospasm (narrowing of the airway)
  • trouble breathing


  • heart failure
  • heart attack
  • arrhythmia (irregular heartbeat)
  • bradycardia (slow heartbeat)
  • high and low blood pressure
  • blood clots
  • thrombophlebitis (vein inflammation)


  • thin fragile skin
  • impaired wound healing
  • swelling
  • ecchymosis (spots caused by ruptured blood vessels)
  • petechiae (reddish spot containing blood that appears in skin)
  • stretch marks
  • dry, scaly skin
  • rash
  • redness
  • itching
  • acne
  • increased
  • sweating
  • injection
  • site reaction
  • lightening or darkening of an area of skin
  • abscess
    suppressed reaction to skin tests
  • thinning hair

Endocrine and Metabolism:

  • development of Cushingoid state (abnormal bodily condition caused by excess corticosteroids)
  • moon face (enlargement of chin and forehead)
  • weight gain abnormal fat deposits
  • suppression of pituitary-adrenal axis (a condition that could lead to disabling the body’s responses to physiological stress such as severe infections or trauma)
  • suppression of growth in children
  • abnormal hair growth
  • new symptoms of diabetes


  • stomach ulcer
  • stomach bleeding
  • inflammation of the pancreas and esophagus
  • perforation of the bowel
  • nausea
  • vomiting or altered sense of taste (with rapid administration of large doses)
  • abdominal pain
  • bloating
  • diarrhea
  • indigestion
  • bowl/bladder dysfunction
  • increased appetite


  • Above normal white blood cell count


  • enlarged liver


  • loss of muscle mass
  • muscle weakness
  • muscle pain
  • malaise (feeling of general discomfort or uneasiness)
  • osteoporosis
  • pathological fractures
  • vertebral compression fractures
  • tendon rupture, (particularly of the Achilles tendon)
  • Charcot joint disease (neuropathic arthropathy)
  • pain and inflammation of the tissues surrounding the injection site
  • joint pain


  • seizures
  • headache
  • vertigo
  • pain and tenderness
  • impaired sensation, strength, and reflexes
  • sensation of tingling, tickling, prickling, or burning of a person's skin
  • sensation of heat, cold, numbness
  • twitching
  • light-headedness
  • dizziness
  • drowsiness
  • ringing in the ears
  • tremors
  • fainting
  • amnesia
  • dizziness


  • cataracts
  • increased intraocular pressure glaucoma
  • bulging of the eye
  • blurred or double vision blindness


  • depression
  • emotional instability
  • euphoria (intense feelings of well-being, elation, happiness, excitement and joy)
  • insomnia
  • mood swings
  • personality changes
  • nervousness
  • apprehension
  • confusion
  • thoughts of suicide
  • delusion
  • hallucination
  • confusion
  • schizophrenia
  • anxiety

Sexual Function/Reproduction:

  • menstrual irregularities
  • increased or decreased motility and number of sperm


  • hiccups, fatigue, irritability

Serious Side Effects, How Often They Happen and What to Do About Them

Symptom / effect Talk with your
doctor or
Only if
In all
Burst or bleeding
 ulcers: symptoms of
 which are stomach
 pain, bleeding from
 the back passage,
 black or bloodstained
 stools and/or vomiting
Flare up of a previous
 TB* : symptoms of
 which could be
 coughing blood or pain
 in the chest
Serious allergic
 reaction: symptoms of
 which include rash,
 (especially of the
 severe dizziness and
 trouble breathing
Signs of infection (such
 as persistent
 throat, painful
 urination, eye
High blood pressure
 (symptoms of which
 are headaches or
 generally feeling
 irregular heartbeat
Cramps and spasms
Vision changes
Mental/mood changes
 (such as mood swings,
 depression, suicidal
 thinking, agitation,
Tendon pain
Bone/joint pain
Easy bruising/bleeding
at the injection site
Thinning skin
Poor wound healing
Unusual hair growth
Unusual skin growth

This is not a complete list of side effects. For any unexpected effects while taking DEPO-MEDROL with Lidocaine, contact your doctor or pharmacist.

How to Store It

Store between 15°C and 30°C. Protect from freezing. Keep out of reach and sight of children.

Reporting Suspected Side Effects

You can report any suspected adverse reactions associated with the use of health products to the Canada Vigilance 

Program by one of the following 3 ways:

  • Report online at www.healthcanada.gc.ca/medeffect
  • Call toll-free at 1-866-234-2345
  • Complete a Canada Vigilance Reporting Form and:
    • Fax toll-free to 1-866-678-6789, or
    • Mail to: Canada Vigilance Program

                                 Health Canada

                  Postal Locator 0701D

                  Ottawa, Ontario

                  K1A 0K9

Postage paid labels, Canada Vigilance Reporting
Form and the adverse reaction reporting
guidelines are available on the MedEffect™ Canada
Web site at www.healthcanada.gc.ca/medeffect.

NOTE: Should you require information related to the
management of side effects, contact your health professional.
The Canada Vigilance Program does not provide medical

More information

This document plus the full Product Monograph, prepared for
health professionals can be found at:
or by contacting the sponsor, Pfizer Canada Inc., at: