What Brevibloc is used for and how to use it
Россия
  • Россия
  • Украина

Brevibloc - Consumer Medicine Information

Manufacture: Baxter
Country: Canada
Condition: Atrial Fibrillation, Atrial Flutter, High Blood Pressure (Hypertension), Intra- or Post-op SVT or Hypertension, Supraventricular Tachycardia
Class: Cardioselective beta blockers, Group II antiarrhythmics
Form: Liquid solution, Intravenous (IV)
Ingredients: esmolol hydrochloride, glacial acetic acid usp, hydrochloric acid nf, sodium acetate trihydrate usp, sodium chloride usp, sodium hydroxide, water for injection usp

BREVIBLOC PREMIXED Injection

(esmolol hydrochloride)

About this Medication

What the medication is used for

  • BREVIBLOC is used to manage rapid heart rates and high blood pressure during surgical operations when there is a risk for heart attacks.
  • BREVIBLOC is also used to rapidly control the heart rate in patients with rapid or irregular heart rhythm.

What it does

BREVIBLOC is classified as a beta-adrenergic receptor blocking agent which blocks the actions of the involuntary nervous system which affects the heart. It is quick-acting and has a short duration of action.

When it should not be used

BREVIBLOC Injection / BREVIBLOC PREMIXED Injection is not for use in chronic settings.

BREVIBLOC should not be used in patients:

  • With low blood pressure
  • With a slow heart rate
  • With heart block problems [Second and third degree A-V block]
  • With abnormally high blood pressure in the arteries of the lung
  • With a disease in the natural pacemaker (conduction system) of the heart
  • Who are using medications to manage heart conditions or maintain their blood pressure (see Note)
  • With heart failure
  • With shock caused by a decreased heart output
  • With an untreated tumour of the adrenal gland
  • Who are allergic to esmolol hydrochloride or any of the nonmedicinal ingredients (see the section What the nonmedicinal ingredients are)

Note: Your physician will determine if BREVIBLOC should be administered. This medication is only administered by a physician familiar with its effects.

What the medicinal ingredient is

Esmolol Hydrochloride

What the non-medicinal ingredients are

Glacial Acetic Acid USP, Hydrochloric Acid NF, Sodium Acetate Trihydrate USP, Sodium Chloride USP, Sodium Hydroxide, Water for Injection USP

What dosage forms it comes in

Solution, 10 mg/mL
BREVIBLOC INJECTION: 10 mL vials
BREVIBLOC PREMIXED INJECTION: 250 mL bags

Warnings and Precautions

Serious Warnings and Precautions
DURING THE ADMINISTRATION OF BREVIBLOC INJECTION / BREVIBLOC PREMIXED INJECTION PATIENTS SHOULD BE CAREFULLY MONITORED, WITH PARTICULAR ATTENTION TO HEART RATE AND BLOOD PRESSURE.

BEFORE you use BREVIBLOC Injection / BREVIBLOC PREMIXED Injection talk to your doctor if you:

  • Have a heart condition or low blood pressure
  • Have kidney disease where you cannot remove enough acid from your body or if for other reasons you have generalized acidosis
  • Have a body temperature below 35°C
  • Are taking any prescription and/or over the counter medications
  • Are diagnosed with Prinzemetal's angina
  • Are pregnant, plan to become pregnant, or are breastfeeding
  • Are taking medications which increase potassium levels in your blood
  • Have hyperthyroidism
  • Have blood volume that is too low
  • Have peripheral circulatory disorders
  • Have psoriasis
  • Have muscle weakness
  • Have impaired renal function
  • Have asthma, bronchitis or other conditions causing bronchial spasm

Interactions with this Medication

Talk to your doctor if you are taking any prescription and/or over the counter medications, especially the medications listed below:

  • Medicines used to treat high blood pressure including clonidine, guanfacine, moxonidine, and reserpine
  • Medicines used to treat heart rhythm problems, chest pain (angina), or heart failure (e.g., verapamil, diltiazem, digoxin)
  • Medicines used to treat diabetes, including insulin and medicines taken by mouth
  • 'Tricyclic' antidepressant medicines (e.g. imipramine and amitriptyline) or any other drugs for mental health problems
  • Epinephrine, such as Epi-Pen, which is used to treat allergic reactions
  • Warfarin (Coumadin), which is used to thin your blood
  • Morphine, which is a strong pain killer
  • Medicines used to treat low blood pressure (e.g. norepinephrine, epinephrine, and dopamine) that are usually administered at the hospital
  • Medications used to treat asthma (e.g. isoproterenol and terbutaline)
  • Suxamethonium chloride (also known as succinylcholine or scoline), which is used to relax your muscles, and inhalation anesthetics. Brevibloc may prolong the effects of some medications you may receive during anesthesia and surgery.

Proper Use of this Medication

Usual dose

Your physician will decide what dose of BREVIBLOC Injection / BREVIBLOC PREMIXED Injection you will receive.

The safety and effectiveness of BREVIBLOC Injection / BREVIBLOC PREMIXED Injection in children (younger than 18 years of age) and elders (65 years of age and older) have not been established.

This medication is for short term use only (up to 24 hours).

Overdose

In case of drug overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

Side Effects and what to do about them

Serious side effects, how often they happen and what to do about them

Symptom / effectTalk with your
doctor or
pharmacist
Stop
taking
drug and
call your
doctor or
pharmacist
Only if
severe
In all
cases
Very CommonLow blood
pressure (with
dizziness
lightheadedness
or excessive
sweating)
CommonSlow heart rate
Abnormal heart
rate and
shortness of
breath
Nausea
Vomiting
Skin
inflammation or
hardening at the
injection site
Headache
Dizziness
Somnolence
(feeling sleepy)
Confusion
Agitation
Fatigue (feeling
tired)
Dyspnea (shortness of
breath)
UncommonVentricular
extrasystoles
(heart palpitations)
Visual
impairment
Abdominal pain
Constipation
Dyspepsia
(upset stomach
or indigestion)
Dry mouth
Skin
discoloration
Weakness
(asthenia)
Fever or chills,
cold sweat
Musculoskeletal
pain
(midscapular
pain) - (pain in
your muscles
/tendons,
including
around the
shoulder blades
and ribs)
Syncope
(fainting)
Convulsion
Speech Disorder
Abnormal
thoughts
Anxiety
Irritability
Difficult or
painful
urination
Wheezing
Rales or rhonchi
(abnormal
rattling/crackling
sounds when
breathing)
Nasal
congestion
Pallor or
Flushing
Sensation of
numbness,
burning or
tingling

This is not a complete list of side effects. For any unexpected effects while taking BREVIBLOC Injection / BREVIBLOC PREMIXED Injection, contact your doctor or pharmacist.

How to Store it

For vial, store at 15°C to 25°C.
For premixed bag store at 15°C to 25°C. Protect from freezing. Avoid excessive heat.

Reporting Suspected Side Effects

You can report any suspected adverse reactions associated with the use of health products to the Canada Vigilance Program by one of the following 3 ways:

  • Report online at www.healthcanada.gc.ca/medeffect
  • Call toll-free at 1-866-234-2345
  • Complete a Canada Vigilance Reporting Form and:
    • Fax toll-free to 1-866-678-6789, or
    • Mail to: Canada Vigilance Program
      Health Canada
      Postal Locator 0701D
      Ottawa, Ontario
      K1A 0K9

Postage paid labels, Canada Vigilance Reporting Form and the adverse reaction reporting guidelines are available on the MedEffect Canada Web site at www.healthcanada.gc.ca/medeffect.

NOTE: Should you require information related to the management of side effects, contact your health professional. The Canada Vigilance Program does not provide medical advice.

More Information

This document plus the full product monograph, prepared for health professionals, can be obtained by contacting the sponsor, Baxter Corporation, at:
1-888-719-9955